Red agaricus for pain relief: routes of action and benefits
Studies on the influence of the red mushroom (Amanita muscaria) on inflammatory processes and pain are of great interest. Today, they are being conducted in scientific institutions in different parts of the world, and the interest is growing every day.
The first study that we would like to introduce you to was conducted in Brazil and the Department of Biochemistry and Molecular Biology, the Laboratory of Neurobiology of Pain and Inflammation, the Department of Physiological Sciences and a number of other Federal Universities of the country participated in its conduct, and the results of the study were published in the "International Journal
The main goal of the study was to evaluate the possible anti-inflammatory and analgesic effects of the polysaccharides of the red amanita mushroom. For this purpose, two main types of polysaccharides were selected:
fucomannoglucan - a polysaccharide consisting of fucose, mannose and galactose, has the ability to modulate the body's immune response) β-d-glucan - a polysaccharide that has immunomodulatory properties and can contribute to improving the immune response.
The studies were performed on mice, and the results and time were recorded and analyzed using tests and software.
The results of this study showed that red fly agaric has analgesic and anti-inflammatory effects:
reduction of neurogenic pain (early phase) by 64%
91% reduction in inflammatory pain (late phase)
reducing inflammatory processes in the body by reducing the release of pro-inflammatory mediators, such as cytokines (peptides and proteins that play an important role in the regulation of the immune system and inflammatory processes).
The results of this study showed that the polysaccharides isolated from the red mushroom affect various signaling pathways in the body, which allows to effectively reduce inflammation and pain.
A follow-up study, published in Frontiers in Pharmacology in April 2023, by the National Research Council of Canada's Nanotechnology Research Center and the University of Alberta's Institute for Neuroscience and Mental Health, aimed to evaluate the effects of agaricus amanita extract on neurogenic and inflammatory pain
The study revealed that several important anti-inflammatory processes take place in the body when using red amanita to reduce pain and inflammation:
1. Activation of macrophages and production of cytokines:
Macrophages are immune cells that engulf and destroy microbes, damaged cells, and other harmful particles. Proinflammatory cytokines are signaling molecules released by immune system cells that regulate the inflammatory response. dsRNA (double-stranded RNA) activates macrophages, which leads to the production of proinflammatory
2. Effect on GABA receptors:
Muscimol is an agonist of GABA receptors, which are the main inhibitory receptors in the central nervous system. Stimulation of GABA receptors reduces the excitation of neurons, which leads to a decrease in pain signals and a decrease in inflammation.
3. Immunomodulating properties of polysaccharides:
Red amanita polysaccharides stimulate the immune system, increasing the activity of natural killers (NK cells) and macrophages. This helps to strengthen the immune response and reduce inflammation.
4. Antioxidant effect:
Red agaric contains antioxidants that reduce oxidative stress associated with inflammation. Antioxidants protect cells from damage caused by free radicals, which reduces the inflammatory response.
5. Influence on glutamate receptors:
Ibotenic acid acts on glutamate receptors, which are the main excitatory receptors in the central nervous system. This can alter the transmission of pain and inflammation signals, helping to reduce their intensity.
6. Increase in the level of interleukins and other mediators of inflammation:
Interleukins (IL-1β, IL-6) and tumor necrosis factor alpha (TNF-α) are key mediators of inflammation. Red mushroom increases the immune response to infection and damage, helping to reduce inflammation.The results of this study demonstrate that red amanita helps to fight inflammation by activating the immune system, stimulating the production of anti-inflammatory cytokines, influencing the receptors of the central nervous system and reducing oxidative stress. These processes help to reduce inflammation, reduce pain and improve the general condition of the body.
Summarizing the results of both studies, we have confirmation that agaricus can effectively suppress both neurogenic and inflammatory pain, has a two-way effect on the immune system: reducing inflammation due to the inhibition of pro-inflammatory cytokines and increasing the anti-inflammatory response, which makes it promising for wide use as an alternative
So, if you have inflammatory diseases that are accompanied by pain, pay attention to the red mushroom, visit our store and start improving your life today!
You can also buy them in our store.
1.Amanita fruits
2.Amanita capsules
3.Amanita extract
4.Mushroom ground
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